Author: Gu, Jiang; Gong, Encong; Zhang, Bo; Zheng, Jie; Gao, Zifen; Zhong, Yanfeng; Zou, Wanzhong; Zhan, Jun; Wang, Shenglan; Xie, Zhigang; Zhuang, Hui; Wu, Bingquan; Zhong, Haohao; Shao, Hongquan; Fang, Weigang; Gao, Dongshia; Pei, Fei; Li, Xingwang; He, Zhongpin; Xu, Danzhen; Shi, Xeying; Anderson, Virginia M.; Leong, Anthony S.-Y.
Title: Multiple organ infection and the pathogenesis of SARS Document date: 2005_8_1
ID: rqjeacow_2
Snippet: We report here on our postmortem study of 18 patients who had suspected SARS who died 14-62 d after the onset of symptoms. In addition, blood samples were examined from 22 cases of confirmed SARS, 3-29 d after the onset of symptoms. We also investigated the immune cell lesion in 100 patients who had suspected SARS who were admitted to our hospitals; 35 were found retrospectively to have been misdiagnosed. We set out to verify a hypothesis of immu.....
Document: We report here on our postmortem study of 18 patients who had suspected SARS who died 14-62 d after the onset of symptoms. In addition, blood samples were examined from 22 cases of confirmed SARS, 3-29 d after the onset of symptoms. We also investigated the immune cell lesion in 100 patients who had suspected SARS who were admitted to our hospitals; 35 were found retrospectively to have been misdiagnosed. We set out to verify a hypothesis of immune cell injury-based damage for the pathogenesis of SARS. Analysis of our newly obtained histologic and molecular data, and clinical information revealed a more complete picture of the infection. RESULTS 8 of the 18 suspected SARS victims were confirmed as having SARS by demonstration of the pathogen with real-time RT-PCR, in situ hybridization, and electron microscopy (EM). All cases had similar pathologic changes in their lungs, immune system, and other organs. Differences in the severity of pathologic changes were noted among SARS cases, which varied with the duration of the disease before death. The examination of the blood samples from patients who had early-stage SARS provided insights into the pathologic changes at the early phase of the disease. Dis-tinct differences in lymphocyte counts between confirmed and misdiagnosed cases also were demonstrated. These are reported in the following text.
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