Selected article for: "high throughput and host response"
Author: Kshirsagar, Meghana; Carbonell, Jaime; Klein-Seetharaman, Judith
Title: Multitask learning for host–pathogen protein interactions
  • Document date: 2013_7_1
    • ID: sdgt2ms5_2
    Snippet: Key to the infection process are host-pathogen interactions at the molecular level, where pathogen proteins physically bind with human proteins. Via these protein interactions, the pathogen manipulates important biological processes in the host cell, evades host immune response and multiplies within the host. Interactions between host and pathogen proteins can be studied using small-scale biochemical, biophysical and genetic experiments or large-.....
    Document: Key to the infection process are host-pathogen interactions at the molecular level, where pathogen proteins physically bind with human proteins. Via these protein interactions, the pathogen manipulates important biological processes in the host cell, evades host immune response and multiplies within the host. Interactions between host and pathogen proteins can be studied using small-scale biochemical, biophysical and genetic experiments or large-scale high-throughput screening methods like yeast two-hybrid (Y2H) assays. Databases like PHI-base (Winnenburg et al., 2008) , PIG (Driscoll et al., 2009) , HPIDB (Kumar and Nanduri, 2010) , PHISTO (Tekir et al., 2012) aggregate host-pathogen protein interactions from several small-scale and high-throughput experiments via manual literature curation. These databases are valuable sources of information for developing models of the modus operandi of pathogens.

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