Author: Tan, Zhaoli; Gao, Lihua; Wang, Yan; Yin, Huihui; Xi, Yongyi; Wu, Xiaojie; Shao, Yong; Qiu, Weiyi; Du, Peng; Shen, Wenlong; Fu, Ling; Jia, Ru; Zhao, Chuanhua; Zhang, Yun; Zhao, Zhihu; Sun, Zhiwei; Chen, Hongxing; Hu, Xianwen; Xu, Jianming; Wang, Youliang
Title: PRSS contributes to cetuximab resistance in colorectal cancer Document date: 2020_1_1
ID: tymoeyoo_11
Snippet: To test whether aberrantly up-regulated PRSS1 expression is sufficient to drive cellular resistance to cetuximab, we overexpressed the mature peptide and full-length peptide of PRSS1 in DiFi cells and LoVo cells. qPCR analysis showed that PRSS1 was overexpressed in DiFi cells (fig. S1F) and LoVo cells (fig. S1G), and ELISA analysis showed that secreted PRSS1 was overexpressed by DiFi cells (Fig. 1J ) and LoVo cells (Fig. 1K ). PRSS1 overexpressio.....
Document: To test whether aberrantly up-regulated PRSS1 expression is sufficient to drive cellular resistance to cetuximab, we overexpressed the mature peptide and full-length peptide of PRSS1 in DiFi cells and LoVo cells. qPCR analysis showed that PRSS1 was overexpressed in DiFi cells (fig. S1F) and LoVo cells (fig. S1G), and ELISA analysis showed that secreted PRSS1 was overexpressed by DiFi cells (Fig. 1J ) and LoVo cells (Fig. 1K ). PRSS1 overexpression significantly increased cellular resistance to cetuximab, suggesting that increased PRSS1 expression correlates with a worse response to cetuximab in colon cancer cell lines (Fig. 1 , L and M).
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