Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_5
Snippet: HBV encodes a multifunctional viral oncoprotein HBx. It acts as a transcriptional activator that modestly activates cellular transcription factors including CREB, NF-B and AP1 (17) . HBx is required for HBV transcription and productive infection in vivo (18, 19) . HBx does not bind DNA. Its ability to activate HBV promoters is mediated through CREB (10, 20) . Mechanistically, HBx enhances CREB dimerization and potentiates coactivator function of .....
Document: HBV encodes a multifunctional viral oncoprotein HBx. It acts as a transcriptional activator that modestly activates cellular transcription factors including CREB, NF-B and AP1 (17) . HBx is required for HBV transcription and productive infection in vivo (18, 19) . HBx does not bind DNA. Its ability to activate HBV promoters is mediated through CREB (10, 20) . Mechanistically, HBx enhances CREB dimerization and potentiates coactivator function of p300/CBP (20, 21) . However, the interplay among HBx, CREB and CRTCs in HBV transcription remains to be understood. Particularly, it will be of interest to see whether and how HBx interacts with and modulates CRTC activity.
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