Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_29
Snippet: To determine the requirement of CREB in CRTCinduced activation of HBV replication, we employed A-CREB, a previously described dominant inactive form of CREB (34) . The expression of A-CREB abrogated CRTC1-induced augmentation of cccDNA formation in pHBV1.3D-transfected HepG2 cells ( Figure 3D , group 4 compared to 2 and 3). Consistent with this, the increase in cccDNA level in the presence of CRTC1 in HepG2.2.15 cells was blunted when A-CREB was .....
Document: To determine the requirement of CREB in CRTCinduced activation of HBV replication, we employed A-CREB, a previously described dominant inactive form of CREB (34) . The expression of A-CREB abrogated CRTC1-induced augmentation of cccDNA formation in pHBV1.3D-transfected HepG2 cells ( Figure 3D , group 4 compared to 2 and 3). Consistent with this, the increase in cccDNA level in the presence of CRTC1 in HepG2.2.15 cells was blunted when A-CREB was overexpressed ( Figure 3E , group 3 compared to 1 and 2). Thus, CREB is required for CRTC1-induced activation of HBV replication.
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