Selected article for: "CRTC1 activation and HBV infection"
Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription
  • Document date: 2014_11_10
    • ID: qtoygz6w_53
    Snippet: CREB and CRTCs have oncogenic potential in various types of cancer (44, 45) . Our present study reveals a novel function of CRTC1 in HBV transcription and replication. The stabilization and activation of CRTC1 were observed both in HepG2 cells freshly transfected with pHBV1.3D and in HepG2.2.15 cells constitutively harboring HBV genome (Figures 2 and 6 ). CRTC1 might plausibly play a role in both acute and chronic phase of HBV infection. However,.....
    Document: CREB and CRTCs have oncogenic potential in various types of cancer (44, 45) . Our present study reveals a novel function of CRTC1 in HBV transcription and replication. The stabilization and activation of CRTC1 were observed both in HepG2 cells freshly transfected with pHBV1.3D and in HepG2.2.15 cells constitutively harboring HBV genome (Figures 2 and 6 ). CRTC1 might plausibly play a role in both acute and chronic phase of HBV infection. However, it will still be of importance to characterize in more detail the stabilization of CRTC1 in different phases of HBV infection and HCC development. Particularly, further investigations are required to clarify whether CRTC1 might be critical in HBV reactivation as well as initiation and progression of HCC.

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