Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_177
Snippet: Clinical features included dwarfism and dullness, known as cretinism and seen with CH in all species, but also constipation and megacolon which are unique to cats with CH. Pedigree analysis documented an autosomal recessive mode of inheritance. Affected kittens developed a goiter and had low serum thyroxine (T4) and triiodothyronine (T3) when compared to controls, but high thyroid stimulating (TSH) hormone levels indicating thyroid dyshormonogene.....
Document: Clinical features included dwarfism and dullness, known as cretinism and seen with CH in all species, but also constipation and megacolon which are unique to cats with CH. Pedigree analysis documented an autosomal recessive mode of inheritance. Affected kittens developed a goiter and had low serum thyroxine (T4) and triiodothyronine (T3) when compared to controls, but high thyroid stimulating (TSH) hormone levels indicating thyroid dyshormonogenesis. Oral thyroid supplementation corrected the progression of clinical signs and prevented further constipation and reversed the megacolon.
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