Author: Nordén, Rickard; Magnusson, Jesper; Lundin, Anna; Tang, Ka-Wei; Nilsson, Staffan; Lindh, Magnus; Andersson, Lars-Magnus; Riise, Gerdt C; Westin, Johan
Title: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation Document date: 2018_3_6
ID: zhlvvuj4_41
Snippet: It remains to be clarified in which cell types TTV replication occurs, but CD4+ T cells and CD8 + 57+ T cells appear to be important for controlling the infection, whereas EBV resides within the B-cell pool and is controlled by CD4+ and CD8+ T cells [14, 15, 17, 21, 22, [38] [39] [40] [41] . In this work, we show that the choice of calcineurin inhibitor affects the TTV-but not the EBV-DNA levels, possibly reflecting separate mechanisms for viral .....
Document: It remains to be clarified in which cell types TTV replication occurs, but CD4+ T cells and CD8 + 57+ T cells appear to be important for controlling the infection, whereas EBV resides within the B-cell pool and is controlled by CD4+ and CD8+ T cells [14, 15, 17, 21, 22, [38] [39] [40] [41] . In this work, we show that the choice of calcineurin inhibitor affects the TTV-but not the EBV-DNA levels, possibly reflecting separate mechanisms for viral replication rather than merely ablation of the T-cell pool. As the choice of immunosuppressive regimen was made at the discretion of the treating physician, these findings should be interpreted with caution but warrant further investigation.
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