Research Communications of the 24th ECVIM-CA Congress

Correlation analyses revealed a significant positive correlation between S100A12 and calprotectin (r = 0.77; p < 0.001). The optimal cut-off value for fecal calprotectin concentration was 49.1 lg/g, which was associated with a sensitivity of 53.3% and a specificity of 86.7% (AUC=0.698; P = 0.049). The optimal cutoff value for fecal S100A12 concentration was 173.7 ng/g, which was associated with a sensitivity of 93.3% and a specificity of 60% (AUC=0.782; P = 0.001). The sensitivity for fecal S100A12 was higher than that for fecal calprotectin (p = 0.019). No significant difference was observed for the specificity of these two markers (p = 0.215). 20 out of the 30 dogs (67%) had concordant results for S100A12 and calprotectin tests. Among these 20 dogs, 11 presented with a CCECAI <12 and 8 of these 11 dogs had both markers below their cut-off values. Among the 9 dogs with a CCECAI≥12, 8 dogs had both markers above their cutoff values. 66% of dogs (19/29) presented histologic signs of inflammation. Sensitivities for fecal calprotectin and S100A12 concentrations for histopathological intestinal inflammation were 42% and 68%, respectively, and specificities were 80% and 30%, respectively.