Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_374
Snippet: The serum concentrations of Group A cats that remained on 0.125 mg/kg were 29.8 AE 2.5 ng/ml whereas those switched to 0.25 mg/kg were 51.2 AE 7.8 ng/ml. When data from groups A and B were pooled, a sigmoidal relationship between percentage baseline SBP and serum [amlodipine] was found. Estimated values of lowest percentage baseline blood pressure on treatment (Emax) was 83.1 AE 1.7%, with an EC 50 value of 10.4 AE 2.6 ng/ ml and a slope function.....
Document: The serum concentrations of Group A cats that remained on 0.125 mg/kg were 29.8 AE 2.5 ng/ml whereas those switched to 0.25 mg/kg were 51.2 AE 7.8 ng/ml. When data from groups A and B were pooled, a sigmoidal relationship between percentage baseline SBP and serum [amlodipine] was found. Estimated values of lowest percentage baseline blood pressure on treatment (Emax) was 83.1 AE 1.7%, with an EC 50 value of 10.4 AE 2.6 ng/ ml and a slope function of 2.5 AE 1.2. The serum concentration required to reduce blood pressure by 15% was estimated to be 20 ng/ml.
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