Author: Michael P McRae; Glennon W Simmons; Nicolaos J Christodoulides; Zhibing Lu; Stella K Kang; David Fenyo; Timothy Alcorn; Isaac P Dapkins; Iman Sharif; Deniz Vurmaz; Sayli S Modak; Kritika Srinivasan; Shruti Warhadpande; Ravi Shrivastav; John T McDevitt
Title: Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19 Document date: 2020_4_22
ID: h4lsvgxo_6
Snippet: In this study, we describe our most recent work toward developing the programmable bio nano chip (p-BNC) with the capacity to learn 17 and adapting it to the task of assessing COVID-19 disease severity. This multiplex and multiclass platform has been demonstrated previously for the detection and quantitation of protein biomarkers, small molecules, and cellular markers in applications such as oral cancer, ovarian cancer, prostate cancer, drugs of .....
Document: In this study, we describe our most recent work toward developing the programmable bio nano chip (p-BNC) with the capacity to learn 17 and adapting it to the task of assessing COVID-19 disease severity. This multiplex and multiclass platform has been demonstrated previously for the detection and quantitation of protein biomarkers, small molecules, and cellular markers in applications such as oral cancer, ovarian cancer, prostate cancer, drugs of abuse, cardiac heart disease, and trauma. [18] [19] [20] [21] Previously, we developed the Cardiac ScoreCard system for predicting a spectrum of cardiovascular disease. 22 This scoring system combines multiple risk factors and biomarker measurements to provide personalized reports for a range of disease indications with diagnostic and prognostic models for cardiac wellness, acute myocardial infarction, and heart failure. The new study described here leverages our past experiences developing clinical decision support tools to efficiently adapt our flexible platform for the development of a prognostic test for COVID-19.
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