Selected article for: "selective soat1 inhibitor and SOAT1 protein"
Title: Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017
  • Document date: 2017_11_7
    • ID: roslkxeq_158
    Snippet: The aim of this study was to determine whether the use of a selective SOAT1 inhibitor such as ATR-101 could have potential in the treatment of canine ATs. To this end, we evaluated the SOAT1 mRNA expression with RT-qPCR in 59 ATs (44 carcinomas and 15 adenomas) and 12 normal adrenals (NAs), and protein expression with immunohistochemistry (IHC) in 47 ATs (36 carcinomas and 11 adenomas) and 4 NAs. Slides were stained with polyclonal rabbit-anti-hu.....
    Document: The aim of this study was to determine whether the use of a selective SOAT1 inhibitor such as ATR-101 could have potential in the treatment of canine ATs. To this end, we evaluated the SOAT1 mRNA expression with RT-qPCR in 59 ATs (44 carcinomas and 15 adenomas) and 12 normal adrenals (NAs), and protein expression with immunohistochemistry (IHC) in 47 ATs (36 carcinomas and 11 adenomas) and 4 NAs. Slides were stained with polyclonal rabbit-anti-human antibody and antibody specificity was confirmed with western blot. A semiquantitative H-score for SOAT1 protein expression was calculated by multiplying the area of positive staining with the staining intensity grading score.

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