Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

Feces had decreased richness between day 0 and 6 weeks (P < 0.001) only. In OP samples, richness increased at 6 and 36 weeks versus day 0 (P = 0.036 and 0.02, respectively). No significant change in relative abundance of predominant taxa was found in fecal or OP samples over time. In BAL, richness significantly decreased from day 0 to 6 and 36 weeks (mean #OTUs 96, 47 and 21, respectively; P < 0.001). Relative abundance of Pseudomonadaceae decreased from day 0 to 36 weeks (68% to 0.12%; P < 0.001) with increases in Sphingobacteriaceae, and Bradyrhizobiaceae (from 0.08% to 52.16% and from 0.40% to 32.58%; P < 0.001). Within BAL, PERMANOVA detected significant differences (P < 0.001) in diversity between samples collected at day 0 and week 36 compared to all other time-points.