Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_22
Snippet: To identify proteins that are specifically expressed in HBVinfected liver, we performed a pilot proteomic profiling study using human liver tissues that are infected with HBV. We noted that CRTC1, but not CRTC2 or CRTC3, was more abundantly detected in infected versus uninfected samples (data not shown). We previously showed the requirement of CRTC coactivators in transcriptional activation of human T-cell leukemia virus type 1 (15) . We therefor.....
Document: To identify proteins that are specifically expressed in HBVinfected liver, we performed a pilot proteomic profiling study using human liver tissues that are infected with HBV. We noted that CRTC1, but not CRTC2 or CRTC3, was more abundantly detected in infected versus uninfected samples (data not shown). We previously showed the requirement of CRTC coactivators in transcriptional activation of human T-cell leukemia virus type 1 (15) . We therefore sought to investigate the expression and function of CRTC1 in HBV-infected cells.
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