Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_4
Snippet: CRTCs are potent coactivators of CREB-dependent transcription from both canonical cellular CREs and the non-canonical viral CREs found in the long terminal repeats of the oncogenic retrovirus human T-cell leukemia virus type 1 (14, 15) . There are three isoforms of human CRTCs, namely CRTC1, CRTC2 and CRTC3. They interact with CREB and cooperate with p300/CBP to potentiate CREB-dependent transcription (15) . Because various signals converge on CR.....
Document: CRTCs are potent coactivators of CREB-dependent transcription from both canonical cellular CREs and the non-canonical viral CREs found in the long terminal repeats of the oncogenic retrovirus human T-cell leukemia virus type 1 (14, 15) . There are three isoforms of human CRTCs, namely CRTC1, CRTC2 and CRTC3. They interact with CREB and cooperate with p300/CBP to potentiate CREB-dependent transcription (15) . Because various signals converge on CRTCs to exert their effects on the transcription of CREB-regulated genes, they are the targets of pharmaceutical agents such as metformin, a widely prescribed drug for type II diabetes (16) . Thus, full characterization of the roles of CRTCs in HBV transcription might reveal new targets for therapeutic intervention.
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