Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_40
Snippet: We next examined the impact of HBx on the steady-state levels of endogenous CRTC proteins in HepG2 cells. No-tably, escalating dose of HBx expression correlated with increased levels of CRTC1 and CRTC2, but not CRTC3 (Figure 7B, lanes 2 and 3 compared to 1) . On the other hand, when we overexpressed CRTCs individually, more prominent HBx bands including the slow-migrating species were visible ( Figure 7C, lanes 2-4 compared to 1) . In other words.....
Document: We next examined the impact of HBx on the steady-state levels of endogenous CRTC proteins in HepG2 cells. No-tably, escalating dose of HBx expression correlated with increased levels of CRTC1 and CRTC2, but not CRTC3 (Figure 7B, lanes 2 and 3 compared to 1) . On the other hand, when we overexpressed CRTCs individually, more prominent HBx bands including the slow-migrating species were visible ( Figure 7C, lanes 2-4 compared to 1) . In other words, CRTC1 and its homologs were capable of stabilizing HBx.
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