Selected article for: "CRTC1 HBx mutual stabilization and mutual stabilization"
Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription
  • Document date: 2014_11_10
    • ID: qtoygz6w_50
    Snippet: The mutual stabilization of HBX and CRTC1/2 in HBVinfected cells (Figure 7 ) is attributed at least in part to their interaction ( Figure 6 ). This stabilization unlikely occurs at the mRNA level since CRTC mRNAs remained unchanged in pHBV1.3D-transfected cells ( Figure 1C ) in which HBx was abundantly expressed ( Figure 1B ). In addition, the stabilization of HBx was seen not only when it was expressed from a plasmid in transfected HepG2 cells b.....
    Document: The mutual stabilization of HBX and CRTC1/2 in HBVinfected cells (Figure 7 ) is attributed at least in part to their interaction ( Figure 6 ). This stabilization unlikely occurs at the mRNA level since CRTC mRNAs remained unchanged in pHBV1.3D-transfected cells ( Figure 1C ) in which HBx was abundantly expressed ( Figure 1B ). In addition, the stabilization of HBx was seen not only when it was expressed from a plasmid in transfected HepG2 cells but also when it was expressed in HepG2.2.15 cells from its own promoter in the HBV genome (Figure 7) , which is not responsive to CRTCs (Figure 2 ). The mechanism by which HBx and CRTC1/2 proteins mutually stabilize each other warrants further study. First, the functional domains in HBx and CRTC1/2 that mediate their interaction and stabilization should be determined. CRTC3 is more divergent from CRTC1/2 and smaller in size; comparative analysis might reveal why CRTC3 was not stabilized by HBx (Figure 7) .

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