Author: Rappuoli, Rino; Bottomley, Matthew J.; D’Oro, Ugo; Finco, Oretta; De Gregorio, Ennio
Title: Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design Document date: 2016_4_4
ID: uyoerxvu_13_1
Snippet: Abs directed against one specific antigen. To start from an enriched antigen-specific B cell population, most studies have used PBMCs isolated at day 8 after immunization, when there is the peak of circulating plasmablasts. Yet, this approach entails a loss of information on the longitudinal evolution of the B cell memory repertoire and eventually of bNAbs and their maintenance in the long-term memory population......
Document: Abs directed against one specific antigen. To start from an enriched antigen-specific B cell population, most studies have used PBMCs isolated at day 8 after immunization, when there is the peak of circulating plasmablasts. Yet, this approach entails a loss of information on the longitudinal evolution of the B cell memory repertoire and eventually of bNAbs and their maintenance in the long-term memory population.
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