Selected article for: "deep sequencing and high throughput"
Author: Rappuoli, Rino; Bottomley, Matthew J.; D’Oro, Ugo; Finco, Oretta; De Gregorio, Ennio
Title: Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
  • Document date: 2016_4_4
    • ID: uyoerxvu_8
    Snippet: 2000: The first vaccine candidates based on antigens discovered by genomics are reported (Pizza et al., 2000) . Reverse vaccinology 2.0 Genomics, high-throughput protein expression, animal models, human monoclonals, B cell repertoire deep sequencing, proteomics, and structure-based antigen design: Genomics is used not only for antigen discovery, but also for antigen expression, conservation, and for epidemiology. Human monoclonals are used to ide.....
    Document: 2000: The first vaccine candidates based on antigens discovered by genomics are reported (Pizza et al., 2000) . Reverse vaccinology 2.0 Genomics, high-throughput protein expression, animal models, human monoclonals, B cell repertoire deep sequencing, proteomics, and structure-based antigen design: Genomics is used not only for antigen discovery, but also for antigen expression, conservation, and for epidemiology. Human monoclonals are used to identify protective antigens/epitopes. Structural characterization of the Ab-antigen complex is used to instruct antigen design.

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