Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS Document date: 2018_12_19
ID: r79h9yzz_1052
Snippet: We analyzed the activities of MMPâ€7 using casein SDSâ€page zymography in the serum of WHWTs with CIPF (n=28), healthy WHWTs (n=27) and healthy dogs of other breeds (n=12). CIPF diagnosis was based on high resolution computed tomography or postâ€mortem lung histopathology (25/28 of CIPF WHWTs and 23/27 healthy WHWTs) or on typical clinical findings. The health of other breed dogs was verified by clinical examinations. MMPâ€7 activities were s.....
Document: We analyzed the activities of MMPâ€7 using casein SDSâ€page zymography in the serum of WHWTs with CIPF (n=28), healthy WHWTs (n=27) and healthy dogs of other breeds (n=12). CIPF diagnosis was based on high resolution computed tomography or postâ€mortem lung histopathology (25/28 of CIPF WHWTs and 23/27 healthy WHWTs) or on typical clinical findings. The health of other breed dogs was verified by clinical examinations. MMPâ€7 activities were significantly higher in CIPF WHWTs (median 0.32, interquartile range [IQR] 0.17â€0.67, range 0.039â€2.16) compared to healthy WHWTs (median 0.16, IQR 0.12â€0.29, range 0.029â€0.55), p=0.0095. MMPâ€7 activity was detected only in one of the other breed healthy dogs (median 0, IQR 0, range 0â€0.17). These results indicate that MMPâ€7 is a potential biomarker also in WHWTs with CIPF. However, we noted increased activities also in healthy WHWTs which can be connected to the breed susceptibility to CIPF.
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