Selected article for: "AIP mutation and hydrocarbon receptor"
Title: Research Communications of the 24th ECVIM-CA Congress
  • Document date: 2015_1_10
    • ID: r59usk02_192
    Snippet: Exon 1 encodes for a region of the AIP protein considered essential for AIP-AIP receptor interaction. Although 70 different human AIP mutations have been identified to date, a human AIP:c9G>T mutation has not yet been identified. The AIP N-terminal is required for the stability of the AIP protein-AIP-receptor complex, and essential for the regulation of translocation into the nucleus, where it binds to aryl hydrocarbon receptor nuclear translocat.....
    Document: Exon 1 encodes for a region of the AIP protein considered essential for AIP-AIP receptor interaction. Although 70 different human AIP mutations have been identified to date, a human AIP:c9G>T mutation has not yet been identified. The AIP N-terminal is required for the stability of the AIP protein-AIP-receptor complex, and essential for the regulation of translocation into the nucleus, where it binds to aryl hydrocarbon receptor nuclear translocator leading to activation of genes thought to act as tumor suppressors. Loss of normal AIP activity is thought to promote somatotrophinoma development. It is therefore possible that the detected AIP:c.9G>T mutation predisposed to somatotrophinoma tumorigenesis in the two affected patients, and a study containing a larger number of cases is indicated.

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