Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_192
Snippet: Exon 1 encodes for a region of the AIP protein considered essential for AIP-AIP receptor interaction. Although 70 different human AIP mutations have been identified to date, a human AIP:c9G>T mutation has not yet been identified. The AIP N-terminal is required for the stability of the AIP protein-AIP-receptor complex, and essential for the regulation of translocation into the nucleus, where it binds to aryl hydrocarbon receptor nuclear translocat.....
Document: Exon 1 encodes for a region of the AIP protein considered essential for AIP-AIP receptor interaction. Although 70 different human AIP mutations have been identified to date, a human AIP:c9G>T mutation has not yet been identified. The AIP N-terminal is required for the stability of the AIP protein-AIP-receptor complex, and essential for the regulation of translocation into the nucleus, where it binds to aryl hydrocarbon receptor nuclear translocator leading to activation of genes thought to act as tumor suppressors. Loss of normal AIP activity is thought to promote somatotrophinoma development. It is therefore possible that the detected AIP:c.9G>T mutation predisposed to somatotrophinoma tumorigenesis in the two affected patients, and a study containing a larger number of cases is indicated.
Search related documents:
Co phrase search for related documents- normal AIP activity loss and protein aip receptor: 1
- normal AIP activity loss and receptor interaction: 1
- normal AIP activity loss and somatotrophinoma development: 1
- normal AIP activity loss and somatotrophinoma development promote: 1
- normal AIP activity loss and translocation regulation: 1
- nuclear translocator and protein aip receptor: 1
- nuclear translocator and receptor interaction: 1
- nuclear translocator and somatotrophinoma development: 1
- nuclear translocator and somatotrophinoma development promote: 1
- nuclear translocator and translocation regulation: 1
- protein aip receptor and receptor interaction: 1
- protein aip receptor and somatotrophinoma development: 1
- protein aip receptor and somatotrophinoma development promote: 1
- protein aip receptor and translocation regulation: 1
- receptor interaction and somatotrophinoma development: 1
- receptor interaction and somatotrophinoma development promote: 1
- receptor interaction and translocation regulation: 1
- somatotrophinoma development and translocation regulation: 1
- somatotrophinoma development promote and translocation regulation: 1
Co phrase search for related documents, hyperlinks ordered by date