Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_300
Snippet: A novel HS cell line (HSC) was established and characterized from primary tumour tissue collected from a dog with disseminated disease. HSC cells were most consistent with interstitial dendritic cell origin based on CD1a, CD11c, and MHC II staining as well as demonstrable phagocytic activity. HSC cells also displayed expression of CCR2, unlike the established DH82 line, supporting a notion that HS consists of a variety of subtypes. CCR2 has been .....
Document: A novel HS cell line (HSC) was established and characterized from primary tumour tissue collected from a dog with disseminated disease. HSC cells were most consistent with interstitial dendritic cell origin based on CD1a, CD11c, and MHC II staining as well as demonstrable phagocytic activity. HSC cells also displayed expression of CCR2, unlike the established DH82 line, supporting a notion that HS consists of a variety of subtypes. CCR2 has been linked to HS growth and metastasis, suggesting it may represent a possible therapeutic target. Further studies establishing and characterising canine HS cells may contribute to the elucidation of mechanisms of tumourigenesis.
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