Research Communications of the 24th ECVIM-CA Congress

Twelve healthy Beagle dogs were randomly allocated to a placebo-group (n = 6) and to a treatment group (n = 6; hydrocortisone-group). The placebo-group received an empty gelatin capsule PO q12 h, whereas the hydrocortisone-group was treated with hydrocortisone at a dose of 8.5 mg/kg PO q12 h. Serum samples were obtained at baseline and on day 1, 5, 28, 56, and 84 during treatment as well as day 1, 5, 28, 56, and 84 post-treatment for all dogs. Serum ca 1 -PI concentrations were measured at all time points using an in-house radioimmunoassay. A Mann-Whitney U test was used to compare the baseline measurements of both groups. The effect of hydrocortisone-treatment on serum ca 1 -PI concentrations was evaluated by comparing ca 1 -PI at baseline and during treatment and between baseline and posttreatment period using a MANOVA.