Selected article for: "gene expression and specific effect"
Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription
  • Document date: 2014_11_10
    • ID: qtoygz6w_45
    Snippet: CRTC1 is particularly stabilized in HBV-infected cells (Figure 1 ). This stabilization effect is specific to CRTC1 (Figure 1 ). Although CRTC2 and CRTC3 expression was not found to be elevated in HBV-infected cells, they were also capable of occupying the preS2 promoter, stabilizing HBx and activating HBV transcription (Figures 2, 3 and 7) . In other words, they are fully competent to regulate HBV gene expression. Because they might be induced an.....
    Document: CRTC1 is particularly stabilized in HBV-infected cells (Figure 1 ). This stabilization effect is specific to CRTC1 (Figure 1 ). Although CRTC2 and CRTC3 expression was not found to be elevated in HBV-infected cells, they were also capable of occupying the preS2 promoter, stabilizing HBx and activating HBV transcription (Figures 2, 3 and 7) . In other words, they are fully competent to regulate HBV gene expression. Because they might be induced and acti-vated in response to metabolic stress and hormones (33) , further studies are required to elucidate how they modulate HBV transcription under the influence of their metabolic and hormonal activators.

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