Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_52
Snippet: Results from our gain-of-function and loss-of-function assays consistently supported the requirement of CRTC1 for HBV replication, as indicated in the production of pgRNA, cccDNA and secreted HBsAg (Figures 3 and 4) . This is generally consistent with the notion that CRTC1regulated HBV transcription is influential in viral replication. The decline of cccDNA level upon CRTC1 suppression ( Figure 4 ) is noteworthy. It raises one interesting possibi.....
Document: Results from our gain-of-function and loss-of-function assays consistently supported the requirement of CRTC1 for HBV replication, as indicated in the production of pgRNA, cccDNA and secreted HBsAg (Figures 3 and 4) . This is generally consistent with the notion that CRTC1regulated HBV transcription is influential in viral replication. The decline of cccDNA level upon CRTC1 suppression ( Figure 4 ) is noteworthy. It raises one interesting possibility that compromising CRTC1 might destabilize cccDNA. Histone hypoacetylation is known to regulate cccDNA transcription (43) . APOBEC3-mediated cytidine deamination has recently been shown to trigger specific degradation of cccDNA (8) . Whether and how CRTC1 recruitment to cccDNA and its post-translational modifications might affect cccDNA stability and function merit further investigations.
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