Selected article for: "binding domain and RBD domain"
Author: Park, Donghyun; Huh, Hee Jae; Kim, Yeon Jeong; Son, Dae-Soon; Jeon, Hyo-Jeong; Im, Eu-Hyun; Kim, Jong-Won; Lee, Nam Yong; Kang, Eun-Suk; Kang, Cheol In; Chung, Doo Ryeon; Ahn, Jin-Hyun; Peck, Kyong Ran; Choi, Sun Shim; Kim, Yae-Jean; Ki, Chang-Seok; Park, Woong-Yang
Title: Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus
  • Document date: 2016_11_23
    • ID: xgp2vx6o_14
    Snippet: Interactions Between Genetic Variants As described above, there was a tight linkage between positions 22984 and 23041-the variant at one position and the wild type at the other position or vice versa (i.e., D510G and I529; D510 and I529T). Based on the genetic linkage, a functional relationship was expected between the variants at these two positions. In fact, these two mutations were located in one of the two major binding patches in the recepto.....
    Document: Interactions Between Genetic Variants As described above, there was a tight linkage between positions 22984 and 23041-the variant at one position and the wild type at the other position or vice versa (i.e., D510G and I529; D510 and I529T). Based on the genetic linkage, a functional relationship was expected between the variants at these two positions. In fact, these two mutations were located in one of the two major binding patches in the receptor-binding domain (RBD), where escape mutations from neutralizing antibodies were previously reported (Tang et al. 2014) .

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