Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS Document date: 2018_12_19
ID: r79h9yzz_223
Snippet: Fibrosis and extracellular matrix remodeling has a causative role in the pathophysiology of cardiac diseases of different origin. At cellular level, fibrotic processes are prior to clinical manifestation of symptoms. Currently there is no biomarker, which is able to detect heartâ€specific fibrosis and remodeling in the peripheral blood sample despite it's advantages in cardiac diagnostics and monitoring of therapy. Previously, using microarray m.....
Document: Fibrosis and extracellular matrix remodeling has a causative role in the pathophysiology of cardiac diseases of different origin. At cellular level, fibrotic processes are prior to clinical manifestation of symptoms. Currently there is no biomarker, which is able to detect heartâ€specific fibrosis and remodeling in the peripheral blood sample despite it's advantages in cardiac diagnostics and monitoring of therapy. Previously, using microarray method we identified heartâ€specific gene expression profile representing fibrotic and inflammatory processes in the peripheral whole blood of tachypacingâ€induced cardiomyopathy model dogs and we successfully selected a heartâ€specific fibrosis related mRNAâ€panel which gene expression levels in blood samples clearly differentiated clinical cases from healthy dogs. MicroRNAs are key regulators of gene expression and highly stable molecules thus ideal biomarker candidates.
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