Research Communications of the 24th ECVIM-CA Congress

The study was financially supported by the Swedish Juvenile Diabetes Foundation, the Fredrik and Ingrid Thuring Foundation, the Magnus Bergvall Foundation, the Lars Hierta Memorial Foundation, and the Foundation for Research, Agria Insurance Company. Feline acromegaly is an increasingly recognised endocrinopathy among diabetic cats, caused by chronic excessive growth hormone secretion by a functional somatotrophinoma in the pars distalis of the anterior pituitary gland. The majority of human somatotrophinomas are sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline mutations of the aryl-hydrocarbon-receptor interacting protein (AIP). Feline acromegaly has phenotypic and biochemical similarities to human familial acromegaly with AIP mutations, such as male predominance, somatotroph macroadenoma and resistance to octreotide therapy.