Selected article for: "canine chronic enteropathy and disease activity"
Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS
  • Document date: 2018_12_19
    • ID: r79h9yzz_693
    Snippet: Canine chronic enteropathy (CE) is an idiopathic gastrointestinal disorder characterized by chronic gastrointestinal signs. Leucine rich alpha‐2‐glycoprotein (LRG) has recently been identified as a novel biomarker of human inflammatory bowel disease, Crohn's disease, and ulcerative colitis (UC). Serum LRG concentrations correlate well with the clinical and endoscopic disease activity in UC. Unlike other acute‐phase proteins, such as C‐rea.....
    Document: Canine chronic enteropathy (CE) is an idiopathic gastrointestinal disorder characterized by chronic gastrointestinal signs. Leucine rich alpha‐2‐glycoprotein (LRG) has recently been identified as a novel biomarker of human inflammatory bowel disease, Crohn's disease, and ulcerative colitis (UC). Serum LRG concentrations correlate well with the clinical and endoscopic disease activity in UC. Unlike other acute‐phase proteins, such as C‐reactive protein, LRG is reportedly expressed not only by hepatocytes, but also by intestinal epithelial cells. The expression of LRG protein is elevated in the intestinal mucosae from patients with UC. Therefore, the aim of this study was to examine the expression of LRG mRNA and protein in the duodenal mucosae of dogs with CE.

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