Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS Document date: 2018_12_19
ID: r79h9yzz_217
Snippet: In referred dogs with MMVD, eight clientâ€owned dogs have been treated with a regimen of overdose of pimobendan (case patients; 0.9~2.7mg/kg daily for 60~240 days). Among patients treated with a recommended dosage of pimobendan (0.4~0.6mg/kg daily for 60~345 days), controls (n=12) were selected based on matching variables such as signalment/medical history, physical examination findings, and severity of CHF. For the initial analysis of homogenei.....
Document: In referred dogs with MMVD, eight clientâ€owned dogs have been treated with a regimen of overdose of pimobendan (case patients; 0.9~2.7mg/kg daily for 60~240 days). Among patients treated with a recommended dosage of pimobendan (0.4~0.6mg/kg daily for 60~345 days), controls (n=12) were selected based on matching variables such as signalment/medical history, physical examination findings, and severity of CHF. For the initial analysis of homogeneity between case and control groups, comprehensive blood test profile (CBC, serum biochemistry, NTâ€proBNP, SDMA), electrocardiographic, radiographic, and echocardiographic data were collected. Serum cardiac troponin I (cTnI) and QTc interval values (formula of Van de Water) were compared between groups. In addition, these two endpoints were analyzed to assess the relationship to the dosage and the duration of administration of pimobendan in the case patients.
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