Author: Dziwenka, Margitta; Coppock, Robert; Alexander, McCorkle; Palumbo, Eddie; Ramirez, Carlos; Lermer, Stephen
Title: Safety Assessment of a Hemp Extract using Genotoxicity and Oral Repeat-Dose Toxicity Studies in Sprague-Dawley Rats Document date: 2020_2_20
ID: u9msvq70_51
Snippet: In the study being reported both the treated and control male rats had the same incidence and severity of vacuolization of the adrenal zona fasciculata and the adrenal weights were significantly increased in the Group 4 females. The vacuolization of the adrenal zona fasciculata and increased adrenal weights were not observed in Groups 5 to 8. The histopathological lesions noted in the adrenal glands in the current study was seen in both control a.....
Document: In the study being reported both the treated and control male rats had the same incidence and severity of vacuolization of the adrenal zona fasciculata and the adrenal weights were significantly increased in the Group 4 females. The vacuolization of the adrenal zona fasciculata and increased adrenal weights were not observed in Groups 5 to 8. The histopathological lesions noted in the adrenal glands in the current study was seen in both control and high dose males and is not considered to be due to treatment with test article and not toxicologically relevant.
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