Author: Angelini, Megan M.; Akhlaghpour, Marzieh; Neuman, Benjamin W.; Buchmeier, Michael J.
Title: Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles Document date: 2013_8_13
ID: yl1qyh7j_9
Snippet: Both full-length and truncated forms of nsp3 induce DMB and MGV. Single transfection of both full-length nsp3 and nsp3C yielded similar phenotypes. Both appeared capable of causing the Fig. 2A) . In a time course immunofluorescence experiment, the nsp3 hollow structures grew larger as time progressed, with the hollow centers being first visible at 12 h posttransfection (Fig. 2D ). The nsp3N construct appeared to be dispersed throughout the cytopl.....
Document: Both full-length and truncated forms of nsp3 induce DMB and MGV. Single transfection of both full-length nsp3 and nsp3C yielded similar phenotypes. Both appeared capable of causing the Fig. 2A) . In a time course immunofluorescence experiment, the nsp3 hollow structures grew larger as time progressed, with the hollow centers being first visible at 12 h posttransfection (Fig. 2D ). The nsp3N construct appeared to be dispersed throughout the cytoplasm in immunofluorescence (Fig. 2B ) and showed no distinct phenotype in electron microscopy.
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