Selected article for: "cell viability and cortisol synthesis"
Title: Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017
  • Document date: 2017_11_7
    • ID: roslkxeq_163
    Snippet: AA dose-dependently decreased cortisol concentration in ACTH-stimulated adrenocortical cells with an IC 50 value of 24.2 nM (P < 0.0001). At the highest AA concentration of 10 µM, the average suppression of cortisol synthesis was 92.5% (SEM AE 3.5). The mRNA expression of CYP17, 3b-HSD and Ki67 was not significantly altered after incubation with AA. Finally, AA did not significantly affect adrenocortical cell viability......
    Document: AA dose-dependently decreased cortisol concentration in ACTH-stimulated adrenocortical cells with an IC 50 value of 24.2 nM (P < 0.0001). At the highest AA concentration of 10 µM, the average suppression of cortisol synthesis was 92.5% (SEM AE 3.5). The mRNA expression of CYP17, 3b-HSD and Ki67 was not significantly altered after incubation with AA. Finally, AA did not significantly affect adrenocortical cell viability.

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