Selected article for: "hematologic malignancy and hmpv infection"
Author: Chu, Helen Y.; Renaud, Christian; Ficken, Elle; Thomson, Blythe; Kuypers, Jane; Englund, Janet A.
Title: Respiratory Tract Infections Due to Human Metapneumovirus in Immunocompromised Children
  • Document date: 2014_10_21
    • ID: ujvbm6ae_8
    Snippet: Overall, 55 hMPV-infected immunocompromised patients were identified from May 29, 2006 to March 26, 2010. The characteristics of these patients are listed in Table 1 . The median age was 5 years (range, 5 months-19 years), and the majority had a hematologic malignancy as an underlying condition. Of these, most had acute lymphoblastic leukemia (ALL) (n = 21; 88%). The nine solid tumors included Wilms tumor (n = 3; 33%), osteosarcoma (n = 1; 11%), .....
    Document: Overall, 55 hMPV-infected immunocompromised patients were identified from May 29, 2006 to March 26, 2010. The characteristics of these patients are listed in Table 1 . The median age was 5 years (range, 5 months-19 years), and the majority had a hematologic malignancy as an underlying condition. Of these, most had acute lymphoblastic leukemia (ALL) (n = 21; 88%). The nine solid tumors included Wilms tumor (n = 3; 33%), osteosarcoma (n = 1; 11%), and ovarian cancer (n = 1; 11%). Nine (16%) patients were undergoing HSCT. Indications for transplant included aplastic anemia (n = 4; 44%) and severe combined immunodeficiency (SCID) (n = 2; 22%). Eight (15%) patients were solid organ transplant recipients, and all were receiving immunosuppressive therapy. Eight (15%) hMPV infections were acquired nosocomially, while 46 (85%) were community acquired. Of these 46 cases, 24 (52%) patients were hospitalized for evaluation of their hMPV infection.

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