RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

This prospective double blinded study included 18 client‐owned dogs with pIMHA randomized to receive aspirin (loading dose 10mg/kg, then 1mg/kg PO SID, n= 10) or clopidogrel (loading dose 10 mg/kg, then 2 mg/kg PO SID, n=8) in addition to standard therapy. TEG, haematocrit (HCT), platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen concentration, antithrombin (AT) activity and D‐dimers were measured before, and 1 and 4 days after commencing treatment. PM was performed on day 1 and 4. Non‐responders were defined as <50% inhibition of thromboxane A2‐receptor activity (TXA2‐RA) stimulated by arachidonic acid (AA) in the aspirin group and <50% inhibition of ADP‐receptor activity (ADP‐RA) in the clopidogrel group, on day 4. For statistical analysis an Anderson‐Darling test was used to determine normality with variables not meeting assumptions loge transformed. A restricted maximum likelihood model was run for each measurement with fixed effects of treatment, day and their interaction and the random effect of patient. Significance was set at p<0.05.