RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

A double‐blinded, placebo‐controlled trial was performed using 24 healthy adult dogs (median age 3 years, range 2‐7)> Dogs were randomized to 4 groups: placebo, clopidogrel 2‐3mg/kg/d, prednisone 2mg/kg/d, or combined prednisone/clopidogrel PO for 28 days. Attitude, food intake, vomiting, and fecal score were determined daily. Digitally‐captured endoscopy was performed at baseline and days 14 and 28. Mucosal hemorrhages, punctate erosions (PE), invasive erosions (IE), and ulcers in the gastric body, cardia, incisura, and antrum were numerated by 2 blinded investigators (JCW, JT). A value of 201 was assigned for >200 lesions in a region. Clinically‐significant bleeding was defined as ≥15 hemorrhages, ≥5 PE, ≥1 IE, or ≥1 ulcer. Results were compared among groups using mixed model, split‐plot repeated measures ANOVAs and generalized estimating equation proportional odds models. P<0.05 was considered significant.