Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo Document date: 2016_3_14
ID: pwlybr2h_37
Snippet: The RNAi plasmid therapy resulted in significant reductions in the viral titers from the brain, lung, and kidney samples collected on 8 dpi ( Figure 4B ), which were homogenized, serially diluted and assayed to determine the viral titers by IFA. No infectious viral particles were detected in the lungs, kidneys, or brains of the survivors at 15 dpi. The dynamic viral loads in the brains were analyzed by qRT-PCR, which indicated that pSilencer-S an.....
Document: The RNAi plasmid therapy resulted in significant reductions in the viral titers from the brain, lung, and kidney samples collected on 8 dpi ( Figure 4B ), which were homogenized, serially diluted and assayed to determine the viral titers by IFA. No infectious viral particles were detected in the lungs, kidneys, or brains of the survivors at 15 dpi. The dynamic viral loads in the brains were analyzed by qRT-PCR, which indicated that pSilencer-S and pSilencer-M significantly decreased HTNV gene expression on 2, 3 and 4 dpi ( Figure 4C and 4D) .
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