Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo Document date: 2016_3_14
ID: pwlybr2h_37
Snippet: The RNAi plasmid therapy resulted in significant reductions in the viral titers from the brain, lung, and kidney samples collected on 8 dpi ( Figure 4B ), which were homogenized, serially diluted and assayed to determine the viral titers by IFA. No infectious viral particles were detected in the lungs, kidneys, or brains of the survivors at 15 dpi. The dynamic viral loads in the brains were analyzed by qRT-PCR, which indicated that pSilencer-S an.....
Document: The RNAi plasmid therapy resulted in significant reductions in the viral titers from the brain, lung, and kidney samples collected on 8 dpi ( Figure 4B ), which were homogenized, serially diluted and assayed to determine the viral titers by IFA. No infectious viral particles were detected in the lungs, kidneys, or brains of the survivors at 15 dpi. The dynamic viral loads in the brains were analyzed by qRT-PCR, which indicated that pSilencer-S and pSilencer-M significantly decreased HTNV gene expression on 2, 3 and 4 dpi ( Figure 4C and 4D) .
Search related documents:
Co phrase search for related documents- brain kidney and kidney sample: 1
- brain kidney and kidney sample lung: 1
- brain kidney and kidney sample lung brain: 1
- brain kidney and significant reduction: 1, 2
- brain kidney and viral load: 1, 2, 3, 4
- brain kidney lung and gene expression: 1, 2, 3, 4, 5, 6, 7
- brain kidney lung and kidney sample: 1
- brain kidney lung and kidney sample lung: 1
- brain kidney lung and kidney sample lung brain: 1
- brain viral load and gene expression: 1
- brain viral load and viral load: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- brain viral load and viral particle: 1
- gene expression and infectious viral particle: 1, 2, 3
- gene expression and kidney sample: 1, 2
- gene expression and significant reduction: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- gene expression and viral load: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- gene expression and viral particle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- gene expression and viral titer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- infectious viral particle and viral load: 1
Co phrase search for related documents, hyperlinks ordered by date