Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo Document date: 2016_3_14
ID: pwlybr2h_40
Snippet: HTNV infection has emerged as one of the severest infectious diseases threatening global health and has a significant worldwide economic influence [2] . In the present study, we demonstrated that vector-based shRNAs targeting specific sequences in the S and M segments of HTNV inhibited the expression and replication of HTNV in vitro and in vivo. Our results provide a new therapeutic candidate for the treatment of HTNV infections......
Document: HTNV infection has emerged as one of the severest infectious diseases threatening global health and has a significant worldwide economic influence [2] . In the present study, we demonstrated that vector-based shRNAs targeting specific sequences in the S and M segments of HTNV inhibited the expression and replication of HTNV in vitro and in vivo. Our results provide a new therapeutic candidate for the treatment of HTNV infections.
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