Title: Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017 Document date: 2017_11_7
ID: roslkxeq_315
Snippet: Conclusion/Discussion: Several PKIs inhibited lymphoid cell proliferation with good direct activity shown for inhibitors of PLK1, Raf, FLT3, ALK, Pim-kinase, FAK, and Aurora Kinases and these require further (clinical) evaluation. PKIs targeting c-KIT, PDGFR, VEGFR showed variable antiproliferative effects, while PKIs targeting EGFR had little to no inhibitory effect. The PKIs tested showed similar IC50 in both the GL-1 and GL-40 cells suggesting.....
Document: Conclusion/Discussion: Several PKIs inhibited lymphoid cell proliferation with good direct activity shown for inhibitors of PLK1, Raf, FLT3, ALK, Pim-kinase, FAK, and Aurora Kinases and these require further (clinical) evaluation. PKIs targeting c-KIT, PDGFR, VEGFR showed variable antiproliferative effects, while PKIs targeting EGFR had little to no inhibitory effect. The PKIs tested showed similar IC50 in both the GL-1 and GL-40 cells suggesting that P-gp overexpression has no role in tumor resistance to PKIs guaranteeing their value in case of tumor resistance to cystostatic drugs.
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