Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

Disclosures: Disclosures to report. Masitinib tablets were donate by AB Science. A variety of therapies are employed in the management of anal sac apocrine gland adenocarcinoma (ASAGA); including surgery, radiotherapy and chemotherapy. Toceranib phosphate (PalladiaÃ’) has shown anti-cancer activity in dogs with advanced ASAGA, which may be related to receptor tyrosine kinase expression such as KIT, RET and PDGFR. Whilst some patients present with advanced regional nodal metastases (typically to the ilio-sacral lymphatic centre; stage 3b) unfortunately some present with distant metastases which can temper owners' desire to choose aggressive loco-regional therapies including lymph node extirpation or radiotherapy. Indeed such therapies would also not treat the distant metastatic deposits and so systemic therapy would still be a requirement for successful management.