Selected article for: "cell culture and high cost"
Author: Choi, Kang-Seuk
Title: Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines
  • Document date: 2017_7_26
    • ID: vk59ghjm_22
    Snippet: For several decades, the global poultry industry has used live attenuated or killed vaccines to control and prevent ND. Conventional NDV vaccines are highly immunogenic and induce protective immunity in poultry. Importantly, live attenuated NDV vaccines can be administrated in drinking water, eye drops, and sprays, and even via in ovo injection. This makes it possible to vaccinate poultry (especially young birds) on a large scale. NDV vaccines ca.....
    Document: For several decades, the global poultry industry has used live attenuated or killed vaccines to control and prevent ND. Conventional NDV vaccines are highly immunogenic and induce protective immunity in poultry. Importantly, live attenuated NDV vaccines can be administrated in drinking water, eye drops, and sprays, and even via in ovo injection. This makes it possible to vaccinate poultry (especially young birds) on a large scale. NDV vaccines can be combined with other poultry vaccines (i.e., used as polyvalent vaccines) to control economically important poultry diseases. The production of NDV vaccines is highly cost-effective since they grow to very high titers in embryonated SPF chicken eggs and in cell culture. This makes NDV vaccine strains attractive as viral vectors for the development of polyvalent vaccines against pathogens that could devastate the poultry industry [12] .

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