Author: Ishimaru, Daniella; Plant, Ewan P.; Sims, Amy C.; Yount, Boyd L.; Roth, Braden M.; Eldho, Nadukkudy V.; Pérez-Alvarado, Gabriela C.; Armbruster, David W.; Baric, Ralph S.; Dinman, Jonathan D.; Taylor, Deborah R.; Hennig, Mirko
Title: RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus Document date: 2012_12_26
ID: zrbn637z_5
Snippet: In the current work, we demonstrate that a previously overlooked loop-loop kissing interaction involving the conserved Stem-loop 3 embedded within the SARS-CoV pseudoknot occurs under physiological conditions in vitro. We further show that kissing dimer formation plays a role in frameshift-stimulation and modulates the relative abundance of full-length and subgenomic viral RNAs......
Document: In the current work, we demonstrate that a previously overlooked loop-loop kissing interaction involving the conserved Stem-loop 3 embedded within the SARS-CoV pseudoknot occurs under physiological conditions in vitro. We further show that kissing dimer formation plays a role in frameshift-stimulation and modulates the relative abundance of full-length and subgenomic viral RNAs.
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