Selected article for: "loop loop kissing and palindromic sequence"
Author: Ishimaru, Daniella; Plant, Ewan P.; Sims, Amy C.; Yount, Boyd L.; Roth, Braden M.; Eldho, Nadukkudy V.; Pérez-Alvarado, Gabriela C.; Armbruster, David W.; Baric, Ralph S.; Dinman, Jonathan D.; Taylor, Deborah R.; Hennig, Mirko
Title: RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus
  • Document date: 2012_12_26
    • ID: zrbn637z_58
    Snippet: Secondary structures and basepairing patterns for all SARS-CoV variants investigated in this study were characterized using NMR methods. Because the 5 0 -ACU AGU-3 0 palindromic sequence was left intact, even the S3-deletion ÁS3 pk mutant could dimerize and thus efficiently stimulated -1 PRF. On the other hand, the S3L2-ACUucc did not engage in loop-loop kissing interactions, was characterized by an open Loop 2 structure, which destabilized Stem.....
    Document: Secondary structures and basepairing patterns for all SARS-CoV variants investigated in this study were characterized using NMR methods. Because the 5 0 -ACU AGU-3 0 palindromic sequence was left intact, even the S3-deletion ÁS3 pk mutant could dimerize and thus efficiently stimulated -1 PRF. On the other hand, the S3L2-ACUucc did not engage in loop-loop kissing interactions, was characterized by an open Loop 2 structure, which destabilized Stem 3, and its ability to promote -1 PRF was reduced almost 3-fold.

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