Selected article for: "loop sequence and wild type"
Author: Ishimaru, Daniella; Plant, Ewan P.; Sims, Amy C.; Yount, Boyd L.; Roth, Braden M.; Eldho, Nadukkudy V.; Pérez-Alvarado, Gabriela C.; Armbruster, David W.; Baric, Ralph S.; Dinman, Jonathan D.; Taylor, Deborah R.; Hennig, Mirko
Title: RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus
  • Document date: 2012_12_26
    • ID: zrbn637z_62
    Snippet: In conclusion, we demonstrate that the structured third stem of SARS-CoV represents an integral part of the -1 PRF stimulating pseudoknot topology. While the exact functional interplay in the viral lifecycle and timing of Stem 3 folding-unfolding interconversions remain to be determined, our results provide important first insight into a palindromic sequence element embedded into Stem 3 that permit loop-loop kissing formation for efficient -1 PRF.....
    Document: In conclusion, we demonstrate that the structured third stem of SARS-CoV represents an integral part of the -1 PRF stimulating pseudoknot topology. While the exact functional interplay in the viral lifecycle and timing of Stem 3 folding-unfolding interconversions remain to be determined, our results provide important first insight into a palindromic sequence element embedded into Stem 3 that permit loop-loop kissing formation for efficient -1 PRF stimulation, efficient translation of ORF1a/b encoded proteins and relative amounts of sgRNA to remain close to wild-type levels.

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