Selected article for: "high resolution and virus methyltransferase"
Author: Byszewska, Magdalena; Smietanski, Miroslaw; Purta, Elzbieta; Bujnicki, Janusz M
Title: RNA methyltransferases involved in 5' cap biosynthesis
  • Document date: 2015_1_27
    • ID: sz2531mv_24
    Snippet: The study on the process of SL RNA maturation in trypanosomal parasites could benefit from structure analysis of trypanosomal methyltransferases. While the cap0 and cap1 methyltransferases in trypanosomes are relatively closely related to their human counterparts, bioinformatics analyses identified cap2 and cap3/4 methyltransferases as close homologs of the vaccinia virus cap1 methyltransferase. While the analysis of protein-RNA interactions and .....
    Document: The study on the process of SL RNA maturation in trypanosomal parasites could benefit from structure analysis of trypanosomal methyltransferases. While the cap0 and cap1 methyltransferases in trypanosomes are relatively closely related to their human counterparts, bioinformatics analyses identified cap2 and cap3/4 methyltransferases as close homologs of the vaccinia virus cap1 methyltransferase. While the analysis of protein-RNA interactions and search for potential regulatory molecules (e.g., inhibitors) could be guided by homology models developed so far, 47 experimental determination of high resolution structures for cap methyltransferases in trypanosomes would be definitely useful.

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