RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

Several studies have been performed in order to find the best functional test for clinical monitoring of dogs with hyperadrenocorticism (HAC) under trilostane therapy. Despite being controversial, ACTH stimulation test is one of the therapeutic tools currently used for this purpose. When using short‐acting exogenous ACTH (tetracosactide), adrenal reserve stimulation is estimated to be maximal 1h after its administration. However, short‐acting ACTH is not widely available in Europe and in several countries, only the depot formulation is purchasable. To author's knowledge, only one study has evaluated ACTH depot concluding that, for a better stimulation of adrenal reserve in dogs with HAC, blood for peak cortisol should be drawn 3h post stimulation with ACTH, instead of 1h (used in the conventional protocol). To date, little is known about the use of ACTH depot in dogs under trilostane therapy.