Author: Kleinman, Steve; Stassinopoulos, Adonis
Title: Risks associated with red blood cell transfusions: potential benefits from application of pathogen inactivation Document date: 2015_8_25
ID: qlddzgbg_36
Snippet: With regard to cost containment, PI implementation for all components (RBCs/PLTs/plasma) should allow for the discontinuation of some donor screening tests and/or the modification of existing screening protocols. 142 Syphilis testing would no longer be needed as transfusion transmission risk is exceedingly low, serologic testing has limited ability to detect early infection, and PI methods have high efficacy in killing the organism in each compon.....
Document: With regard to cost containment, PI implementation for all components (RBCs/PLTs/plasma) should allow for the discontinuation of some donor screening tests and/or the modification of existing screening protocols. 142 Syphilis testing would no longer be needed as transfusion transmission risk is exceedingly low, serologic testing has limited ability to detect early infection, and PI methods have high efficacy in killing the organism in each component type (shown for PLTs and plasma and still to be verified for PI-RBCs). [143] [144] [145] CMV antibody, Trypanosoma cruzi antibody, and HBsAg testing (assuming that HBV NAT is implemented) could also be eliminated.
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