Author: Ishimaru, Daniella; Plant, Ewan P.; Sims, Amy C.; Yount, Boyd L.; Roth, Braden M.; Eldho, Nadukkudy V.; Pérez-Alvarado, Gabriela C.; Armbruster, David W.; Baric, Ralph S.; Dinman, Jonathan D.; Taylor, Deborah R.; Hennig, Mirko
Title: RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus Document date: 2012_12_26
ID: zrbn637z_55
Snippet: Although a coronavirus frameshift signal was among the first pseudoknots to be identified and has been extensively studied using mutagenesis (7) , the size of the CoV pseudoknots have limited structural analyses at the atomic level. NMR and X-ray crystallography have been used to describe several smaller pseudoknots but the differences between the pseudoknots makes it impossible to extrapolate features from the smaller pseudoknots to the larger o.....
Document: Although a coronavirus frameshift signal was among the first pseudoknots to be identified and has been extensively studied using mutagenesis (7) , the size of the CoV pseudoknots have limited structural analyses at the atomic level. NMR and X-ray crystallography have been used to describe several smaller pseudoknots but the differences between the pseudoknots makes it impossible to extrapolate features from the smaller pseudoknots to the larger ones (5) . From studies of HIV and other retroviruses, it is clear that modulation of frameshift efficiency can have a dramatic effect on virus viability, and the same is true for positive-strand RNA viruses (46, 47) . Recently, it was demonstrated that the SARS-CoV pseudoknot could potentially be a target for antiviral agents making it imperative to understand its structure and function in greater detail (48) .
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